›› 2011, Vol. 23 ›› Issue (3): 226-228.doi: 10.3969/j.issn.1004-616x.2011.03.017

• 检测研究 • Previous Articles     Next Articles

Teratogenicity of lyophilized hirudin powder in rats

HUANG Chao-pei，HE Wei-tao，ZHAO Peng，LI Bin，WANG Yan-wu，FU Wei-zhong，HE Li，SU Ai-rong   

  1. Guangxi Center for Disease Prevention and Control, Nanning 530028, Guangxi, China
  • Received:2010-08-31 Revised:2010-09-29 Online:2011-05-30 Published:2011-05-30
  • Contact: HUANG Chao-pei

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Abstract: To determine the potentially teratogenic effects of lyophilized hirudin powder in rats. METHODS: Sixty pregnant rats were divided randomly into 5 groups, 3 groups treated with lyophilized hirudin powder (contain 3 mg which was equivalent to 50 AT-U natural hirudin per gram) with doses of 312.5, 1 250, 5 000 mg/kg, one negative control(distilled water) and a positive control(300 mg/kg aspirin), 12 pregnant rats in each group. The drugs were given orally for 10 days from 6th to 15th day after gestation. At 20th day the rats were sacrificed to examine the appearance, viscera, bones and physical growth of the fetuses. RESULTS: The body weight of pregnant rats, litter weight, live birth rate, fetal body weight and length in all treated groups were not significantly different from negative control group(P > 0.05), and no abnormality of organ or appearance was observed in the fetuses of treated groups. CONCLUSION: Lyophilized hirudin powder had no maternal toxicity，embryo toxicity and teratogenicity in rats at doses tested.

Key words: lyophilized hirudin powder, rat, embryo toxicity, teratogenicity